Protein name:
Coxsackievirus and adenovirus receptor homolog (CAR;rCAR) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Monomer. Probably homodimer is formed 2 molecules on adjacent cells. Interacts with LNX, MPDZ, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with DNAJC7. Probably part of a complex containing CXADR, HSP90AA1 and DNAJC7.
Function:
Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Cell junction
adherens junction
Cell junction
tight junction
Basolateral cell membrane
Single-pass type I membrane protein
Localized at the intercellular contacts. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface.
Protein Attributes:
50:
MALLLCFVLL | CGVADFTSSL | SITTPEQRIE | KAKGETAYLP | CKFTLEPEDQ |
100:
GPLDIEWLIS | PSDNQKVDQV | IILYSGDKIY | DNYYPDLKGR | VHFTSNDVKS |
150:
GDASINVTNL | QLSDIGTYQC | KVKKAPGVAN | RKFLLTVLVK | PSGTRCFVDG |
200:
SGEIGNDFKL | KCEPKEGSLP | LQYEWQKLSD | SQKMPTPWLA | EMTSPVISVK |
250:
NASSEYSGTY | SCTVQNRVGS | DQCMLRLDVV | PPSNRAGTIA | GAVIGTLLAL |
300:
VLIGAILFCC | HKKRREEKYE | KEVHHDIRED | VPPPKSRTST | ARSYIGSNHS |
350:
SLGSMSPSNM | EGYSKTQYNQ | VPSEDFERAP | QSPTLAPAKV | AAPNLSRMGA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Bovine
Polyclonal Antibody for Rat CAR
Polyclonal Antibody for Rat CAR
Polyclonal Antibody for Rat CAR
Polyclonal Antibody for Rat CAR
Monoclonal Antibody for Rat CAR
Monoclonal Antibody for Rat CAR
Monoclonal Antibody for Rat CAR
Monoclonal Antibody for Rat CAR
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
"Expression of Coxsackie-adenovirus-receptor and alpha v-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers."
Fechner H.
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Haack A.
,
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Eizema K.
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Pauschinger M.
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Poller W.
Gene Ther.6:1520-1535(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-358 (ISOFORM 1);PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
strain :
Wistar .
tissue :
Liver .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Liver .